Episode 6 – Coagulate or Bust: DIC

In this episode, we discuss one of the most dangerous secondary complications seen in the critically ill:  Disseminated Intravascular Coagulation (DIC).  Tune in as we cover the clotting cascade and how opposing treatment regimens may be indicated for your patients depending on the stage of the disease’s progression.


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Boral, B. M., Williams, D. J., & Boral, L. I. (2017). Disseminated intravascular coagulation. American Journal of Clinical Pathology, 146(6), 670-680.

Farkas, J. (2016, December 5). PulmCrit- Coagulation balance in sepsis-associated DIC. Retrieved from https://emcrit.org/pulmcrit/sepsis-dic/

Franchine, M., & Lippi, G. (2012). Fibrinogen replacement therapy: a critical review of the literature. Blood Transfusion, 10(1), 23-27.

Kaneko, T., & Wada, H. (2011). Diagnostic criteria and laboratory tests for disseminated intravascular coagulation. Hematology, 51(2), 67-76.

Ostrowski, S. R., Windelov, N. A., Ibsen, M., Haase, N., Perner, A., & Johansson, P. I. (2013). Consecutive thrombelastography clot strength profiles in patients with severe sepsis and their association with 28-day mortality: a prospective study. Journal of Critical Care, 28(3), 317.

Peyvandi, F., & Palla, R. (2017). Fibrinogen concentrates. Clinical Advances in Hematology and Oncology.

Prothrombin. (2017). Retrieved from https://www.britannica.com/science/prothrombin

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